Herein, we provide a review on best practices for ingredient selection, safety, and efficacy of baby wipes. Therefore, it is important that healthcare professionals have accessible evidenced‐based information on the safety and tolerability of common ingredients found in baby wipes to optimally educate their patients and families. Not all products are made the same, as differences exist in manufacturing processes, ingredients, materials, safety, and quality testing. While disposable baby wipes have been shown to be effective and gentle at cleaning infant skin, even the skin of premature infants, there is growing public concern regarding their safety and tolerability. Therefore, ensuring that baby wipes contain ingredients that are safe and mild on skin is important to help minimize skin irritation and discomfort. The use of wet wipes for infants (baby wipes) is a common practice to clean skin after urine or a bowel movement, and this practice even extends to cleaning the hands and face, resulting in repeated daily use. In the diapered area, the continuous exposure to excess moisture and irritants from urine and feces weakens the stratum corneum, making the skin more susceptible to irritation.

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